Besides this main action, carnitine has other physiological roles, namely detoxification of non metabolizable acyl residues, general buffering of the acylCoA to CoA ratio, and the shuttling of the acyl groups of acylCoAs, such as peroxisomes, cytosol and mitochondria
Similarly, although hepatic dysfunction can occur with large niacin doses (1-3 grams daily over months) causing elevated liver enzymes or jaundice, niacinamide at 100 mg is very unlikely to have any adverse effect on the liver
Un fenmeno similar se observ con Zepbound, aprobado en 2023
Moreover, oral bioavailable formulations of curcumin were safe for human at the dose of 500 mg two times in a day for 30 days, but there are still few trials and more studies are needed specially on nanoformulations and it should be discussed in a separate article
doi: 10.1038/srep41085 (2017)
Another person improved after a short antibiotic course but the benefit faded after the microbiome rebounded and they needed combination strategies focusing on diet and probiotics