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Endocrine Reviews / Physiological Reviews , 85(2), 495522

For glucose control, head-to-head trials have shown that oral semaglutide 14mg produces HbA1c reductions comparable to the injectable form at lower doses, making it a clinically meaningful option for many patients with type 2 diabetes whose primary goal is glucose management with cardiovascular protection

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Due to the presence of heterogeneity in the included studies (I 2 = 74%, P = 0.0002), the random effects model was used (Fig