Friedrich F et al
[5] Altered sleep patterns, difficulty concentrating, irritability, overactivity, excitability, mental depression, confusion and impaired judgement have all been reported in patients receiving 15 mg of folic acid daily for 1 month
Intravenous Administration The way B12 injections are given, either intramuscularly or intravenously, affects how well they work
Anti-inflammatory & cytoprotective actions (GI and beyond)
Certain medications can interfere with B12 levels too
[21] Within cells, cyanocobalamin is converted to methylcobalamin and 5- deoxyadenosylcobalamin, coenzymes that participate respectively in homocysteine remethylation to methionine and in the isomerization of methylmalonyl-CoA to succinyl CoA, reactions essential for DNA synthesis, erythropoiesis, and myelin maintenance