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While glucose is the preferred substrate for energy production in retinal neurons, under certain circumstances, including cell degeneration and glucose-deprived conditions, they use alternate fuel substrates in order to improve metabolic efficiency 9,10,11

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Besides, glutamine stimulates lysosomal translocation and activation of mTORC1 via the small GTPase ARF1 and v-ATPase in RagA and RagB knockout cells without Ragulator contribution [90]