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56 The most common adverse events were gastrointestinal in the preclinical, phase1 and 2 trials similar to trials involving injectable GLP-1 agonists
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Endocrinology 159 , 34463457 (2018)
These include mitochondrial complex I dysfunction, impairment of ATP production, oxidative stress, neuroinflammation, endoplasmic reticulum (ER) stress and aberrant proteolytic degradation
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