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Caffeine does have a mild diuretic effect, meaning it causes you to urinate more and, in some cases, can lead to dehydration

PMID 34582562

Tirzepatide for diabetes (Mounjaro) uses the same dose range as for weight loss (up to 15 mg)

When their sleep was restricted to about 5.5 hours per night, the amount of fat lost dropped by 55%, even though calorie intake stayed the same (Nedeltcheva et al., Annals of Internal Medicine , 2010)

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Red blood cells and DNA both require vitamin B12