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Patients experiencing significant gastrointestinal side effects might benefit from dose reduction before stopping entirely, and those with type 2 diabetes require transition planning to alternative glucose-lowering therapies

[5] [6] Some agents in this class (including liraglutide, semaglutide and dulaglutide) have demonstrated cardiovascular benefits in clinical trials, though specific benefits vary by individual medication

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Every serious complication observed in clinical trials involved dehydration as a contributing factor

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