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This multi-receptor approach may help the body regulate appetite, improve metabolic rate, and support healthier blood sugar levels in a more comprehensive way than single-agonist therapies

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Yoon KH, Cho DC, Yu SH, Kim KT, Jeon Y, Sung JK (2012) The change of bone metabolism in ovariectomized rats: analyses of MicroCT scan and biochemical markers of bone turnover

The activity half-life in rat of exendin-4 in fusion with a carrier antibody has been previously reported as 10.8 h 26 , which is similar to the 11.5 h value we observed in mice for exendin-4 in fusion with the anti-PCSK9 Ab#2 antibody (Supplementary Table 4)