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'If you find something, it will take many years and lots of money to get something that is approved as a drug to use on humans.' Exenatide (commercial name Byetta), the synthetic version of exendin-4, was developed in 1992 but was not approved for use until 2005

These benefits, along with already widespread use and generally good tolerability profile, have piqued interest in the potential benefit of SGLT2i and GLP1-RA in patients with rheumatologic conditions, who are at higher risk of cardiovascular and renal complications

It is a potent antioxidant that can help prevent free radical damage to the skin caused by the sun, pollution, and smoking

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But it is not the only outcome, and in patients with established atherosclerotic disease or heart failure, it may not even be the primary mechanism of benefit