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In stroke, reduced mitophagy and autophagy may hinder the prompt clearance of damaged mitochondria in the brain, leading to a loss of protection from increased reactive oxygen species (ROS) and reduced mitochondrial ATP supply (Frugier et al., 2015)
On the other hand, Wegovy's impact is generally more immediate, with users likely observing some control over their appetite shortly after starting the treatment
doi:10.1289/ehp.118-a22
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Furthermore, potent immunomodulators risk off-target immune activation and systemic cytokine storms if nanocarrier biodistribution is suboptimal (54)
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