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Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer
It supports the growth and activation of immune cells, boosting the body's ability to fight infections and reduce inflammation
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Furthermore, most studies prioritize symptom improvement (e.g., pain reduction) as endpoints, with a pronounced lack of robust evidence demonstrating structural modification (e.g., cartilage preservation via quantitative MRI)
doi: 10.1007/s00394-014-0706-z 28
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