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Once-Weekly Semaglutide in Adults with Overweight or Obesity Primary STEP 1 trial source for semaglutide weight-management efficacy and adverse-event context

Engagement rate for 4 or more weeks based on Noom app engagement data for November 2025 Noom Microdose GLP-1 Rx Program users, based on their first-ever log-in date

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This treatment works best when combined with a healthy diet and regular exercise

The melanocortin system's regulation of energy balance involves not only reduced food intake but also increased energy expenditure through activation of sympathetic nervous system outflow

These are less likely to cause blood sugar spikes