People who drink a lot on a regular basis are more likely to have the CYP2E1 enzyme constantly upregulated, potentially increasing the conversion of acetaminophen into the toxic metabolite, NAPQI
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Arch Biochem Biophys 204:8087 Benight N, Burrin DG, Stoll B (2009) Intestinal metabolism of sulfur amino acids
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Additionally, recent studies from 2024 to 2025 on NGPs highlight the urgent requirement for clearer guidance and harmonized approval procedures (156, 539)