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Study Snapshot Study Type Systematic review of quasi-experimental studies Reports Included 176 reports published from 1993 through 2024 Peer-Reviewed Reports 148 Primary Designs 129 difference-in-differences and 42 interrupted time-series analyses Geography 141 reports used United States data Outcomes Cannabis initiation and use, health-care utilization, alcohol, tobacco, opioids, and decriminalization outcomes Risk of Bias Assessed with a modified ROBINS-I framework Published July 28, 2026 PMID 42520281 DOI 10.1111/1468-0009.70108 Clinical Bottom Line Cannabis-policy liberalization is commonly followed by more adult cannabis use, but downstream effects differ across age groups, policy types, and other substances

The timeline may vary depending on individual responses.

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Restlessness or insomnia

However, fat oxidation requires adequate oxygen (it is an aerobic process) and proceeds more slowly than glucose metabolism

Eating reduced portions but still maintaining reasonable food intake