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The inflammatory response due to the overproduction of ROS was not limited to the increased release of cytokines but also affected blood cells and caused an increase in WBC counts, called leukocytosis
Thomas I, Dickens AM, Posti JP, Czeiter E, Duberg D, Sinioja T, et al
Dose adjustment isnt a guideline checkbox its a clinical safeguard
Evidence summarized by Peptide Sciences notes that copper(II) ions can inhibit type 1 5--reductase activity by up to ~90% in vitro (half-maximal inhibition at ~0.12 g/mL Cu), with substantially less effect on type 2 suggesting follicle-localized DHT suppression without system-wide androgen blockade
Robust causal inference using directed acyclic graphs: the R Package Dagitty