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Not all articles specify which form of B12 was used in the respective study

118 , 2634 (1985) Steere, A

M.WaldmanS

FDA Drug Documents

Options for managing tolerance include a brief dose reduction for 4 to 8 weeks ("drug holiday" at a lower dose, not complete cessation), lifestyle optimization to maximize the medication effect, evaluation for other contributing factors (thyroid function, cortisol, sleep quality, medication interactions), and consideration of adding a complementary compound to address specific aspects of the plateau

Any effect is gradual and works best alongside good sleep habits, nutrition, and training