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Horn, DO, MPH, DABOM, MFOMA, medical director at the University of Texas Center for Obesity Medicine and Metabolic Performance and clinical assistant professor in the department of surgery at University of Texas McGovern Medical School in Houston, said the weight loss observed in ATTAIN-2 was lower than what was observed in ATTAIN-1, but added that adults with type 2 diabetes usually lose less weight with obesity pharmacotherapy than the nondiabetes population
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Semaglutide belongs to a class of drugs called glucagon-like peptide-1 (GLP-1) receptor agonists and is known for its dual benefits: it helps control blood glucose levels in adults with type 2 diabetes and supports weight loss in people with or without diabetes (off-label) when used in combination with diet and increased physical activity
Participants who stayed on through 48 weeks saw A1C reductions averaging 2.02% in those with type 2 diabetes, triglyceride drops of 28%, systolic blood pressure decreases of 6.8 mmHg, and LDL cholesterol reductions of 12%
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