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The error bars in (B) and (D) represent the standard errors of the kobs values estimated separately at each inhibitor concentration, as obtained from nonlinear regression analysis

These results guide the concurrent hormonal rebalancing required for full recovery

Notably, the mobility of most of these atoms decreases upon binding GSH

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Strategies that deplete GSH, such as using inhibitors like BSO which is inhibitor of -glutamylcysteine synthetase (-GCS) , the rate-limiting enzyme in glutathione (GSH) synthesis or by combining prodrug activation with GSH depletion in nanosystems, have shown promise in overcoming MDR and improving chemotherapy effectiveness [72]