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The majority of QIs was reduced back to the respective parent compound (50% of AQ-QI and 80% of DEAQ-QI), presumably by the action of endogenous antioxidants and/or reductases, e.g., quinone reductases ( Figure 5B )

There may be several reasons why these findings were absent in the current study

Glutathione along with cardio vascular support and digestive support was prescribed to the patient for long term use: GSH Hawthorne Berry Coenzyme Q10 Magnesium Probiotic Diet and lifestyle modifications After several months of treatment the patient reported an increase in energy, described as: An increase in the ability to continue gardening without the need for breaks

The best concentration was G2 (1 mM), which resulted in a rise in antioxidant activity

On the other hand, Nr1h3 -knockout mice fed a high-cholesterol and/or HFD develop a MASH-like phenotype 32,52,53

Additionally, one clinical study reported that consumption of chlorogenic acid-enriched coffee not only improved plasma antioxidant capacity and decreased plasma lipid and protein oxidation but also donated to enhancing cardiovascular health in people with hypercholesterolemia [169]