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Panel C shows the cecum pathology scores from Panel A and B in box-and-whisker format along with reference 129 N10 (N = 29)

GBMs are primarily immunosuppressive tumors, and this is primarily due to the high presence of tumor-associated macrophages (TAMs), tumor-associated neutrophils (TANs), and regulatory T cells (Tregs)

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One approach in creating a mitochondria-targeted AT is to bind an antioxidant molecule (e.g., SOD, thiol, vitamin E, BHT, ebselen, CoQ, or various spin traps, such as TEMPO) with a hydrocarbon chain of varying length to the phosphorus of the lipophilic compound triphenylphosphonium (TPP) such as mitoquinol (MitoQ 10