doi: 10.3389/fphar.2025.1543575
It was identified through a medicinal chemistry programme at the University of Texas Health Science Center as the lead NNMT inhibitor candidate among a series of 1-methylquinolinium analogues bearing primary amine substitutions, selected for its combination of high passive membrane permeability (confirmed in PAMPA assays), high active transport membrane permeability (confirmed in bidirectional Caco-2 cell assays), potent NNMT inhibitory activity, and high selectivity including confirmed absence of inhibitory effects on related SAM-dependent methyltransferases or enzymes in the NAD+ salvage pathway
Symptoms can start following an event that affects the body, such as surgery, infection, physical trauma, or severe psychological stress
For further questions on methylene blue and currently available data, feel free to reach out to the FACTS team at [email protected] References: Traumatic Brain Injury & Concussion
The identity of glutathione S-transferase B with ligandin, a major binding protein of liver
BPC-157 dominates for specific injury sites, gut issues, and localised damage