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J Alzheimers Dis 19:311323

Short-term BSO withdrawal effect on in vitro hepatocyte epigenetic modifying enzymes genes, vitamin D metabolism genes and genes associated NAFLD Treatment with BSO for 12 h showed a decline in GSH with an increased in ROS, whereas withdrawal of treatment for a period of 6 h and 12 h replenished the GSH content and decreased ROS in hepatocytes (Fig

One study found that when people with mild cognitive issues and low levels of B12 were given B12 vitamins, most of them showed improved cognitive symptoms

We suppose the change is because the initial doses are enough to keep B12 levels within the desired range

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