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Yes, macrogol preparations such as Laxido and Movicol are well-tolerated for long-term use and are particularly suitable for managing chronic constipation in patients taking GLP-1 medications

A platform like TrumpRx that primarily focuses on branded products is mostly irrelevant for patients who are insured for the medications

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Exclusion criteria included the Concept ID for diagnoses of Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Elevated HbA1C levels (6.5), and conditions that would increase fracture risk, including diagnoses for: Osteoporosis, Rheumatoid Arthritis, Chronic Kidney Disease, and Long-term Corticosteroid Use

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Moreover, treatment groups significantly differed in disease duration at baseline as most patients have not decided for the treatment with GLP-1-RAs until having failed to achieve significant weight loss on their own, which could have affected our results