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In one study, participants took 500 or 1000 mg per day

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The study concluded that the loss of SCFAs contributes to an imbalance in pro- and anti-inflammatory pathways in the CNS, exacerbating neuroinflammation in CKD (Vaziri et al., 2013)

Probably thats why citric acid is usually not used as an exfoliant but more as a helper ingredient in small amounts to adjust the pH of a formulation

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