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Aos 20 anos, a concentrao plasmtica da molcula seria de cerca de 200 ng/mL, caindo para aproximadamente 80 ng/mL aos 60 anos

Over time, additional doses (0.75 mg for titration or low-dose needs, and recently Lilly introduced higher doses 3.0 and 4.5 mg for those needing more effect) expanded its use

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DOI: 10.1016/j.ejphar.2010.10.109