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Prolonged vomiting or diarrhoea can lead to dehydration and, in some cases, acute kidney injury (AKI)
Two independent reviewers (WM and LB) searched the electronic PubMed/MEDLINE, Scielo, Embase and Cochrane Controlled Trials databases using the terms semaglutide or GLP-1RAs combined with acute pancreatitis or gastrointestinal adverse effects or pancreatic adverse effects and extracted data
[2] SGLT2 inhibitors (such as dapagliflozin or empagliflozin) offer cardiovascular and renal benefits alongside glucose-lowering effects and typically produce modest weight loss through urinary glucose excretion
A Closer Look Tirzepatides dosing strategy centers on gradual escalation to optimize tolerability and effectiveness
Development and Expanding Indications of GLP-1 Receptor Agonists In 2005, the United States (US) Food and Drug Administration approved the first GLP-1 receptor agonist, exenatide, for the treatment of type 2 diabetes (T2D)
10.1186/s13287-017-0694-z Summary Keywords GLP-1, GLP-1RAs, T2DM, glucose, mechanism Citation He X, Zhao W, Li P, Zhang Y, Li G, Su H, Lu B and Pang Z (2025) Research progress of GLP-1RAs in the treatment of type 2 diabetes mellitus
