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Although anisonucleosis (polyploidy) is known to occur as an age-related phenomenon, the nuclear and cellular changes can also be induced by xenobiotics (Schoental and Magee 1959

Nonetheless, its relevance to human biology needs to be addressed by more investigations

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This placebo controlled study in 24 elderly individuals showed that a single dose of an NAD+ booster before exercise improved fatigue index, physical recovery and muscle function