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reported in approximately 4060% of participants in higher-dose groups [1] Vomiting reported in approximately 2030% of participants at higher doses Diarrhoea Constipation Decreased appetite (which, whilst contributing to weight loss, can also be uncomfortable) The majority of gastrointestinal events were mild to moderate in severity and tended to diminish over time as participants adjusted to the medication
A study of 6522 patients found that 24 (0.4%) had experienced adverse reactions, the most frequent being anorexia, nausea, vomiting, and rash [29]
Gragnano F et al
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Klotsman M, Anderson WH, Gilor C
It increases our basal metabolic rate (how much energy we burn at rest), meaning we burn more energy throughout the day, and it promotes the breakdown of stored fat for fuel
