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doi: 10.1056/NEJMe2202547 123 IottiS.WolfF.MazurA.MaierJ

Chronic Stress : Stress hormones like cortisol increase oxidative stress, burning through glutathione faster than your body can replenish it

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In animal cells the fate of ITCs is well characterized: conjugation to glutathione by GSTs resulting in its intracellular depletion and subsequent degradation of dithiocarbamates through enzymatic events catalysed by -glutamyltranspeptidase, cysteinylglycinase and N -acetyltransferase via the mercapturic acid pathway 76

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