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(LAC OR Acetyl-L-Carnitine) AND (antidepressant OR antidepression) and their matching synonyms were used for an adequate search strategy

In our model oxidative stress is represented by an elevated level of H 2 O 2 which induces many changes in one-carbon metabolism and the transsulfuration pathway

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Anyway, pro-apoptotic effects were observed in HL60 cells incubated with HOTYR even in conditions not supporting H2O2 accumulation (between 23.8 and 38.0% depending on the media) suggesting that other mechanisms, in addition to the H2O2-releasing activity, could be involved in the pro-apoptotic activity (80)