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This degree of weight loss contributed to the metabolic improvements, though tirzepatides effects on glucose metabolism extend beyond weight loss through direct effects on insulin sensitivity and beta cell function

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Oxidative stress, as reflected by glutathione status, appeared to be an earlier signal than inflammation in the trajectory of age-related cognitive decline

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To determine whether this variant is likely to be causal, we considered all 42 variants within the 99% credible set of the association, and annotated by predicted functional consequence (Supplementary Table 9)