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Presynaptic transient receptor potential channel (TRP channel) receptor activation by PregS modulates glutamate release and increases sEPSC in acutely isolated hilar neurons of the dentate gyrus, an increase that is blocked by TRP channel antagonists (121)
Research efforts are also focused on understanding how variations in experimental design, concentration, and molecular stability may affect compound behavior across different in vitro systems
Blanco MA
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Administration of the 5-reductase inhibitor, finasteride to pregnant rat dams late in gestation impairs cognitive and neuroendocrine function in their juvenile offspring (210)
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