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In the mid-2000s, Novo Nordisk had developed a peptide called liraglutide that mimics the gut hormone glucagon-like peptide-1 (GLP-1), leading to antidiabetic effects and weight loss
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Pulmonary aspiration of gastric contents in two patients taking semaglutide for weight loss
Selective Effects: Ipamorelin exerts its effects primarily on growth hormone release, with minimal impact on other hormones such as thyroid-stimulating hormone, luteinizing hormone, and prolactin
The samples were washed three times with PBS, each time for 5 min
The rationale is elegant: because GLP-1 receptors are enriched in metabolically active brain regions, using GLP-1 as a delivery vehicle allows estrogen to be directed preferentially toward the central nervous system, potentially enhancing its neuroprotective effects while limiting systemic hormonal exposure
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