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The fixed-effect sensitivity analysis preserved the overall directional ordering, supporting the robustness of the main interpretation (Supplementary Appendix 6)

For patients with type 2 diabetes or obesity, tirzepatide represents a well-studied, FDA-approved medication with demonstrated efficacy in clinical trials

If you take oral contraceptives, blood thinners, diabetes medications, or other time-sensitive oral medications, discuss potential interactions with your prescribing clinician before starting treatment

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View Source Peptides Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization 2006 DOI: 10.1016/j.peptides.2005.07.029 PMID: 16277968 Hadley ME, Dorr RT View Source Journal of the American Academy of Dermatology Pigmentary changes in a patient treated with melanotan 2009 DOI: 10.1016/j.jaad.2008.10.044 PMID: 19389525 Cousen P, Colver G, Helbling I View Source International Journal of Impotence Research Erectogenic and behavioral effects of melanotan-II in male rats 2000 DOI: 10.1038/sj.ijir.3900564 PMID: 11079361 Wessells H, Hruby VJ, Hackett J, et al