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GLP-1R agonists may also exert their neuroprotective action increasing level and activity of brain-derived neurotrophic factor, regulating calcium homeostasis, promoting glycolysis, and reducing vascular damage (Du et al., 2022)

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Preclinical studies suggest many ways that ALCAR may benefit the brain

Huang CS, Moore WR, Meister A

However, the intensity of appetite suppression may vary considerably between individuals

However, despite the lack of statistical significance, the authors noted a consistent directional trend toward lower BMD in the semaglutide group at follow-up