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This loss doesn't happen gradually

Iron (Fe 2+ ) derived from hemoglobin metabolism and immune responses, implicated in early ALS pathogenesis via oxidative stress, contributes to motor neuron damage, exacerbating BBB permeability changes [244, 245]

Buckley N and Eddleston M

Iliceto S, Scrutinio D, Bruzzi P, D'Ambrosio G, Boni L, Di Biase M, Biasco G, Hugenholtz PG, Rizzon P

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