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Dose adjustment is not recommended in patients with mild-severe renal impairment (eGFR = 15-89 mL/min/1.73 m 2 ), but use is not recommended for patients with end-stage renal disease (127)
10.1001/jamapsychiatry.2018.3990 JAMA Psychiatry 134 ZammataroM.ChiechioS.MontanaM
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Structurally, tirzepatide is engineered to mimic the primary amino acid sequence of GIP while retaining partial agonistic activity at the GLP-1 receptor
The pharmacological effects of retatrutide fade in direct proportion to the drug leaving your system
Lilly is also working to get orforglipron as an oral obesity medication, which could be a much larger market
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