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It took almost two decades to overcome the challenges of early versions (the median time between target discovery and drug approval has been 25 years ): Shorter half lives: the early version of GLP1s didnt last very long (broken down in GI tract) so people had to take them 2x per day Less Effective: Saxenda, an early GLP1 injectable, resulted in 7-9% weight loss compared to current GLP1s/GIPs that are showing 15%, 17%, 22% and 25% average weight loss (pending drug, dose, phase of trial, population tested)

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