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Leptin, produced by fat cells, signals energy availability to the reproductive system

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This integrated model is useful, but it remains provisional

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This indicates that the primary role of CHAC2 in pluripotency is to restrain the differentiation activity of CHAC1 (Wang et al., 2017)

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Clinical isolates were obtained under an IRB exemption from a pre-existing collection

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While this decline can be part of normal adaptive aging, it may become clinically relevant when combined with chronic circadian disruption, neurodegenerative processes, metabolic disease, or persistent oxidative and inflammatory stress

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