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Mitochondrial impairments in aetiopathology of multifactorial diseases: common origin but individual outcomes in context of 3P medicine

Obes Surg 29(1):314 AziziKia H et al (2024) Periprocedural changes of serum biomarkers in predicting complications following bariatric surgery for obesity: systematic review and meta-analysis

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The activation of PLC results in the release of inositol-1,4,5-trisphosphate (IP 3 ) from membrane associated phosphatidylinositol-4,5-bisphosphate (PIP 2 ), which then binds to specific IP 3 receptors in the endoplasmic reticulum/sarcoplasmic reticulum (ER/SR) resulting in the release of intracellular stores of Ca 2+