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It was first isolated from bovine muscle in 1905 by two Russian scientists [24], and only the L-isomer was found to be bioactive [4]

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It was showed that NP4 treatment leaded to an increase in pro-inflammatory M1-type macrophages and a decrease in anti-inflammatory M2-type macrophages in mouse tumor tissues, with the proportion of M1 to M2 macrophages being 4.4 times higher compared to untreated mouse tumor tissues (Fig

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The exact mechanism may be that LIXI reduces chylomicron triacylglycerol by delaying gastric emptying by increased clearance (69)

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This corresponds to to * and n to * transitions, due to the peptide bond of an -helix

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