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Comparative effectiveness of GLP-1 receptor agonists on glycaemic control, body weight, and lipid profile for type 2 diabetes: systematic review and network meta-analysis BMJ 2024
Phase 1b studies in type 2 diabetes showed dose-dependent HbA1c reductions up to 1.6% and pharmacokinetics supporting once-weekly dosing (t ~6 days)
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Thus, less frequent and smaller meals are recommended, which would predispose patients to biliary sludge, gallstone formation and slowed biliary motility
