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Summary: Most patients notice appetite suppression and early blood glucose improvements within 12 weeks of starting GLP-1 therapy, with measurable weight loss typically appearing after 48 weeks and maximum benefits emerging after several months on the maintenance dose

It has a lot of other anti-inflammatory effects as well

Pujadas, G

People who remain on GLP-1 therapy for 1224 months (rather than stopping after 6 months) show better long-term weight maintenance because their brains have more time to adapt to lower body weight

Take home message As weve covered in this article, there are many reasons why you might not be losing weight on semaglutide

Recommended protocol: Washout: 30 to 35 days (conservative, recommended) Starting dose: 2mg weekly (resist the urge to start higher) Week 5: escalate to 4mg Week 9: escalate to 8mg Week 13: escalate to 12mg Yes, you start at 2mg despite coming from 15mg tirzepatide