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[Abstract]2025 May;14(9):e70855

GLP1/E improves metabolic and gonadal traits in a PCOS model of ovarian dysfunction We next assessed the metabolic, gonadal, and hormonal effects of the intervention with equivalent doses (10 nmol/kg) of GLP1, E, or GLP1/E in PNA mice, which retain ovulatory capacity albeit with clear dysregulation of ovarian cyclicity

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A 2025 Cleveland Clinic study found that individuals with certain genetic profiles were up to 50% more likely not to lose weight on GLP-1 medications, while those with responsive profiles were up to 82% more likely to achieve significant weight loss

In addition to the recent drug shortages of GLP-1s, the high cost of the medications have led many patients to seek compounded alternatives

Across numerous studies, no significant BPC-157 side effects or toxicities have been reported