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Depending on their subcellular localization and the existence of unique cis -acting regulatory elements in the upstream promoter region, various GPX genes respond differently to environmental stresses

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109 The Nrf2 coordinates the basal and stress-inducible activation of the glutamate-cysteine ligase complex 110 and regulates the transcription of glutathione peroxidase 2 and glutathione S-transferases

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When administered via IV, glutathione bypasses the digestive system, allowing for higher absorption and faster effects compared to oral supplements

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