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(1) Treatment of growth hormone deficiency and dwarfism Growth hormon deficiency and dwarfism are diseases caused by insufficient secretion of growth hormon, and patients may experience symptoms such as growth retardation and short stature

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Studies have shown that malfunction and mutation of p53 gene may lead to an escalation in cell proliferation and a reduction in apoptosis, ultimately carcinogenesis, including gastric carcinogenesis ( Waf1/Cip1 and Bax-1 are inhibited, and suppression of p21 Waf1/Cip1 towards cyclin-CDK and proliferating cellular nuclear antigen (PCNA) is diminished, thereby activating the cell cycle

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The application of single-cell RNA sequencing and advancements in neuroimaging, such as PET imaging and MRI, are invaluable for understanding the molecular and cellular underpinnings of BBB dysfunction