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Although butyrate has been proposed to serve as an energy substrate via -oxidation, the specific mechanisms by which microbial metabolites repair diabetes-associated mitochondrial damage and bridge energy supply-hormone secretion remained undefined (Tan et al., 2014

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GLP-1 drugs work to counteract insulin resistance by increasing insulin sensitivity in neurons

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Specifically, while obesity surgery and LIRA/PYY 3-36 co-administration resulted in comparable changes in body weight in obese rats, only surgery resulted in profound changes to the hypothalamic transcriptome

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