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146 In a clinical 2b trial (NCT03008070), Lanifibranor achieved optimal results that patients treated with the 1200-mg dose of Lanifibranor had a decrease of at least two points in the SAF-A score (the activity part of the Steatosis, Activity, Fibrosis (SAF) scoring system) without worsening of fibrosis and reached the primary endpoint, which will ultimately determine the therapeutic potential of pan-PPAR agonist targeting inflammation and fibrosis to support further evaluation of Lanifibranor in the phase 3 trial

Activation of the GH/IGF-1 axis regulates hepatic lipid metabolism