While not studied extensively, there appears to be a series of internal skin factors that are turned off by the GLP-1 drug that cause skin to look duller than usual, more wrinkled, and have more sun-induced pigmentation
10.2174/138161210790945977 117 SikiricP.SeiwerthS.GrabarevicZ.BalenI.AralicaG.GjurasinM.et al (2001)
Brain Res [Internet]
When we seeded Cas9-expressing HCT-8 cells (induced using 0.5 g/mL doxycycline) along with transfection reagent Dharmafect 2 and 10 nM tracrRNA into wells containing 10 nM pooled guides against a particular gene, we found protein levels reduced by 70-80 % three days later (Fig S1D)
While oral semaglutide was cost-effective compared to liraglutide (ICER = $40,100/QALY) and moderately cost-effective versus background treatment ($117,500/QALY) and sitagliptin ($145,200/QALY), it did not meet standard cost-effectiveness thresholds when compared with empagliflozin, with an estimated ICER of approximately $458,400 per QALY
Example: If you weigh 180 lbs, aim for at least 90 ounces of water daily