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3b), despite neurons expressed mito GCL, indicating that GPx1 use of -glutamylcysteine is essential for -glutamylcysteine-mediated O 2 detoxification in this model of excitotoxicity

Its metabolism is closely linked to the transsulfurization branch (providing cysteine), the GSH-GSSG redox cycle (maintaining redox balance), and the detoxification system (completing substance detoxification), forming a complex and efficient metabolic network

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10.1016/j.phymed.2010.08.016 126

Lancet 392 , 21802193 (2018)